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RBPJ Inhibitor-1
CAS No. 2682114-39-0
RBPJ Inhibitor-1 ( —— )
产品货号. M34771 CAS No. 2682114-39-0
RBPJ Inhibitor-1 (RIN1) 是首个 RBPJ 抑制剂，可阻断RBPJ 和SHARP 的相互作用。RBPJ Inhibitor-1 (RIN1) 可抑制 Notch 依赖性的肿瘤细胞的增殖。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥439 | 有现货 |
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| 5MG | ￥646 | 有现货 |
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| 10MG | ￥1122 | 有现货 |
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| 25MG | ￥1869 | 有现货 |
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| 50MG | ￥3230 | 有现货 |
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| 100MG | ￥4559 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称RBPJ Inhibitor-1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述RBPJ Inhibitor-1 (RIN1) 是首个 RBPJ 抑制剂，可阻断RBPJ 和SHARP 的相互作用。RBPJ Inhibitor-1 (RIN1) 可抑制 Notch 依赖性的肿瘤细胞的增殖。
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产品描述RBPJ Inhibitor-1 (RIN1), the first RBPJ inhibitor, blocks the functional interaction of RBPJ with SHARP. RBPJ Inhibitor-1 (RIN1) inhibits NOTCH-dependent tumor cell proliferation.
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体外实验Cell Viability Assay Cell Line:AD-293 cells were transfected with RBPJ-VP16myc.Concentration:2 μM.Incubation Time:17 hours.Result:Inhibited Hes1-Luciferase activity with an IC50 of 0.18 μM and Emax of 82%.Inhibited NOTCH3 ICD with similar potency and efcacy (0.19 μM and Emax=88%).Cell Proliferation Assay Cell Line:T-cell acute lymphoblastic leukemia (T-ALL) patients (Jurkat and KOPT-K1) and in the mantle cell lymphoma (MCL) line REC-1.Concentration:0.1-10 μM.Incubation Time:96 h. Result:Inhibited NOTCH-dependent tumor cell proliferation.
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体内实验——
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同义词——
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通路Neuroscience
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靶点Gamma-secretase
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受体Gamma-secretase
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研究领域——
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适应症——
化学信息
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CAS Number2682114-39-0
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分子量311.31
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分子式C17H14FN3O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 250 mg/mL (803.06 mM; 超声助溶 )
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SMILESO(C1=C(C(N)=O)C=CC(=C1)C=2N(C)N=CC2)C3=C(F)C=CC=C3
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Cecilia Hurtado, et al. Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ. Sci Rep. 2019 Jul 25;9(1):10811.?
